Dealing with Pervasive Transcription

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The Reality of Pervasive Transcription

1 Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia, 2 Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America, 3 Broad Institute, Cambridge, Massachusetts, United States of America, 4 MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, ...

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Response to “The Reality of Pervasive Transcription”

Clark et al. criticize several aspects of our study [1], and specifically challenge our assertion that the degree of pervasive transcription has previously been overstated. We disagree with much of their reasoning and their interpretation of our work. For example, many of our conclusions are based on overall sequence read distributions, while Clark et al. focus on transcript units and seqfrags ...

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Pervasive transcription: detecting functional RNAs in bacteria

Pervasive, or genome-wide, transcription has been reported in all domains of life. In bacteria, most pervasive transcription occurs antisense to protein-coding transcripts, although recently a new class of pervasive RNAs was identified that originates from within annotated genes. Initially considered to be non-functional transcriptional noise, pervasive transcription is increasingly being recog...

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ژورنال

عنوان ژورنال: Molecular Cell

سال: 2013

ISSN: 1097-2765

DOI: 10.1016/j.molcel.2013.10.032